Gout and pseudogout are crystalline arthropathies, that is, diseases producing recurrent attacks of acute inflammatory arthritis due to the deposition of crystals in the joints. Gout is caused by an imbalance in uric acid intake, synthesis or excretion that leads to the periodic deposition of monosodium urate crystals in joints. Pseudogout has a similar clinical presentation, but is due to deposition of a different crystal, calcium pyrophosphate dihydrate (CPPD). Gout is subject to flares and periods of remission, but over time, repeated gouty flares can cause enduring joint damage. Gout usually affects one joint at a time, often the metatarsophalangeal joint of the great toe.

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