Morton's neuroma (also known as an intermetatarsal or interdigital neuroma) is a common cause of forefoot pain. It presents as a sharp, burning sensation in the affected web-space, which often radiates proximally or distally between the adjacent toes; most typically, it is found in the 3-4 or 2-3 intermetatarsal space, which can manifest as pain, burning, and/or numbness between the 3rd and 4th or 2nd and 3rd toes respectively. From a pathological standpoint, note that this condition is not a true neuroma per se. In other words, Morton's neuroma is not a "benign growth of nerve tissue," as any formal definition of neuroma would imply, but rather represents inflammation of the nerve and/or thickening (perineural fibrosis) around it. It is generally agreed that wearing ill-fitted shoes with tapered toe box or high-heels can aggravate this condition.
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