De Quervain’s disease is a common cause of pain at the base of the thumb and the radial side of the wrist. This condition is characterized by irritation of the extensor pollicis brevis and abductor pollicis longus, as they pass through their sheaths in the so-called "first compartment" on the dorsum of the wrist. The cause of de Quervain's disease is often unknown, but repetitive grasping tasks and rheumatoid arthritis are associated with increased incidence. The use of a splint usually leads to relief, but injection with steroids, or failing that, surgical release of the tendon sheath may be needed.
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