Spondyloarthropathy is a group of seronegative inflammatory rheumatic diseases of the spine. The phrase “seronegative” specifically denotes the absence of rheumatoid factor and antinuclear antibodies in the patient’s circulation. The main forms of seronegative spondyloarthropathy are ankylosing spondylitis, reactive arthritis (such as Reiter’s syndrome), psoriatic arthritis and spinal illnesses linked to inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis.
Spondyloarthropathy is characterized by back pain and stiffness. In some cases, there are systemic manifestations affecting the eyes, gastrointestinal tract, and skin. Spondyloarthropathy is associated with joint inflammation and cartilage destruction, which leads to immobility in the musculoskeletal system. Although not detectable with routine blood tests for common antibodies, spondyloarthropathy, especially ankylosing spondylitis, is associated with a higher prevalence of the human leukocyte antigen B27 (HLA-B27) gene.
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