This is a single blinded, randomized clinical trial. Subjects will be male or female with Grade 1,2 or 3 OA of the knee classified based on the radiologic Kellgren -Lawrence grading system.
100 patients will be recruited for this study and 50 patients each will be randomized to one of the treatment groups using block randomization i.e. receiving either treatment IA steroids or IA Prp injections. The patients will be aware and will be consenting to the treatment they will be receiving. An investigator from the research team, blinded to group assignment, will assist patients in completing the Oxford Knee score, WOMAC and SF-12 scores prior to receiving the treatment and at 6 weeks, 3 months and 6 months after receiving the treatment. In addition, they will be followed by regularly (at 3 weeks, 9 weeks, 4 months and 5 months) via telephone to inquire about any side effects of the treatment and to document patient satisfaction. Subjects in both groups will continue to receive concomitant treatments both pharmacological and nonpharmacological. All subjects will receive physiotherapy sessions with their respective intervention.
The duration of this single blinded, prospective randomized trial will therefore be 6 months. Subjects will continue to receive treatment even if they wish to withdraw from the study at any point.
Read more: http://www.clinicaltrials.gov/ct2/show/NCT01923909?cond=%22Arthritis%22&lup_s=08/23/2013&lup_d=30
