Arthritis Clinical Trials

The study include:

100 knees, 50 knees will have single injection of Crespine gel, and 50 knees will have single injection of 2 ampules of Intragel.

The patient will be randomized to Crespine gel or to Intragel.

Inclusion Criteria: patients with Osteoarthritis grade II and III according to Kellgren and Lawrence grading were included.

Exclusion Criteria: patients with autoimmune illnesses, active inflammation or infected processes, anticoagulant, and known allergy to hyaluronic acid.

Target parameters:

• Lower extremity functional scale
• Visual analogue scale
• Range of motion
• Kellgren and Lawrence class grade

Eligibility:

Ages Eligible for Study: 20 years to 70 years Genders Eligible for Study: both Accepts Healthy Volunteers: no

Criteria

Inclusion Criteria:

• Age of patients between 20 and 70 years
• patients with Osteoarthritis grade II and III according to Kellgren and Lawrence grading

Exclusion Criteria:

• Autoimmune illnesses
• Active inflammation or infected processes
• Anticoagulant
• Known allergy to hyaluronic acid.