I go to school in Chicago, but I have noticed some regionalism in where I'm getting my interviews. I did one away in the South and another away in the Midwest, in addition to my home program. The majority of my interviews are in the Midwest and South. That's not to say that I haven't gotten interviews in the East though. Haven't gotten any love at all from California, but I'm not from California, didn't do a rotation out there, and am not an outstanding (ie AOA, Step I >250) applicant. From what I've heard, you should have one of the above if you want to get into a program there. As far as Chicago, this is arguably the 3rd most competitive place besides NYC and California to get into. You have to be outstanding to get in invitation at Northwestern if you didn't rotate, and Rush is also a competitive program to get an interview from. Loyola and UIC are programs that do give out a lot of invites to non-rotators though, but again it's tough because so many people apply to Chicago because it's a great city and there's so many programs here. The chairman at one of the places that I rotated at said that there definitely is some regionalism based on where you rotate and where you go to med school. Programs in the region know more about your med school and the people that come out of there and they may know colleauges at those places too. So if they see a great letter from someone that they know, then of course, your chances are better. Then again, if you get a great letter from someone like Rockwood, then regionalism may not matter and you can get an interview anywhere.