Carpal Tunnel Syndrome is a compression neuropathy of the median nerve as it passes though the carpal tunnel at the wrist. Patients with Carpal Tunnel Syndrome typically present with numbness and tingling in the thumb, index finger and long fingers, as well as nocturnal wrist or hand pain. Prolonged compression of the median nerve (Figure 1) may also lead to thenar muscle weakness and fine motor difficulty. Carpal Tunnel Syndrome is common and costly: its economic costs in the USA alone are estimated to exceed $2 billion per year, where approximately 500,000 carpal tunnel releases are performed per year.

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