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The effect of a biphasic injectable bone substitute on the interface strength in a rabbit knee prosthesis model.
J Orthop Surg Res. 2013 Jul 31;8(1):25
Authors: Zampelis V, Tägil M, Lidgren L, Isaksson H, Atroshi I, Wang JS
Abstract
BACKGROUND: In joint prosthetic surgery, various methods are used to provide implant stability. We used an injectable bone substitute, composed of calcium sulfate/hydroxyapatite, as bone defect filler to stabilize a tibia prosthesis in an experimental rabbit model. The aim of the study was to investigate and compare the stability of prosthetic fixation with and without the use of an injectable bone substitute.
METHODS: Sixteen rabbits were used and the tibia prostheses were implanted bilaterally, one side with the prosthesis alone and the other side with the prosthesis and calcium sulfate/hydroxyapatite (CeramentTM). The rabbits were randomly divided into two groups and euthanized after 6 and 12 weeks, respectively. The prosthesis was extracted measuring the pull-out force in an Instron tester, and the bone surrounding the former prosthesis site was analyzed by histology, histomorphometry, and micro-computed tomography.
RESULTS: At 6 weeks no difference in maximum pull-out force was found between the prostheses fixed with or without CeramentTM. At 12 weeks the maximum pull-out force for the prostheses with CeramentTM was significantly higher than that for the prostheses without CeramentTM (p = 0.04). The
CONCLUSION: We conclude that early prosthesis-bone interface strength is not influenced by a bone substitute. However, during remodeling, the bone substitute might provide improved mechanical support for the prosthesis. The results support further studies of the use of injectable calcium sulfate/hydroxyapatite in fixation of prosthetic joint implants.
PMID: 23899023 [PubMed - as supplied by publisher]
Read more... http://www.ncbi.nlm.nih.gov/pubmed/23899023?dopt=Abstract
