Paget's disease of the bone is a condition of dysregulated bone remodeling, characterized by rapid osteoclastic bone resorption followed by increased osteoblastic bone formation. The resulting new bone is dense but structurally weak. The spine, skull, pelvis, femur, and tibia are the most common sites of disease. Bone overgrowth may cause pain, arthritis, and deformities (the latter giving rise to the condition’s historical name, osteitis deformans). The bone in Paget's disease is also susceptible to fracture. Although rare, a region of bone affected by Paget's disease can undergo malignant transformation into a sarcoma. Many cases of Paget’s disease are asymptomatic...
