A study conducted in Europe and published online in the journal The BMJ examines risk of heart failure linked to use of NSAIDs. 

The authors reviewed information from five population-based databases on 92,163 hospital admissions for heart failure and 8,246,403 control patients. Compared with past NSAID use, they found that current use of any NSAID was associated with a 19 percent increase risk of hospital admission for heart failure. Overall risk of admission for heart failure increased for seven traditional NSAIDs: diclofenac, ibuprofen, indomethacin, ketorolac, naproxen, nimesulide, and piroxicam; and two COX-2 inhibitors: etoricoxib and rofecoxib. Odds ratios ranged from 1.16 for naproxen to 1.83 for ketorolac. In addition, risk of heart failure doubled for diclofenac, etoricoxib, indomethacin, piroxicam, and rofecoxib when used at very high doses (=2 defined daily dose equivalents), and even medium doses (0.9-1.2 defined daily dose equivalents) of indomethacin and etoricoxib were associated with increased risk. The authors found no evidence that celecoxib increased risk of admission for heart failure at commonly used doses. Learn more...