Fewer than 5 percent of cases of Alzheimer's disease have a clear genetic cause, making it hard to predict who will develop the devastating brain-wasting disorder. There is an urgent need to develop biomarkers and early treatments before the symptoms of decline take hold and destroy lives. Now, using a mouse model of Alzheimer's disease, researchers discover a link between early bone loss and brain degeneration that may begin to address this need.
Years before the symptoms emerge, abnormal protein deposits are already forming throughout the brain in people with Alzheimer's disease.The researchers - from Northeast Ohio Medical University (NEOMED) in Rootstown - report their findings in the Journal of Alzheimer's Disease.
