You might miss a few interviews doing an away sub-i thru mid-december...Pitt comes to mind as a program that gets their interviews over with the first week of December.
Also, most programs have deadlines of around Nov 1st for all letters to be in, so I wouldn't count on getting a letter from a rotation that you do that late. If you don't need a letter from that away, then it's not an issue. I did an away that ended in late October and I thought it was still a little too late to get a letter on that rotation.