Spontaneous knee effusion, also known as "water on the knee," can be a primary symptom of Lyme disease, even when patients do not exhibit a "bull's eye" rash, another common Lyme disease symptom. According to a literature review appearing in the November issue of The Journal of the American Academy of Orthopaedic Surgeons (JAAOS), early diagnosis and antibiotic treatment can prevent the development of Lyme disease's more severe symptoms.

Lyme borreliosis, or Lyme disease--the most common vector-borne illness transmitted by insects--is prevalent in the Northeast and upper Midwest regions of the United States.

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