As disconcerting as it may be, everything that has been said regarding regionality (is this even a word?) seems to be true... at least from my experiences this year. I grew up in a military family and only spent 5 of my first 14 years in the U.S.. Since then, I've been in the Northeast for undergrad and medical/graduate school, so I definitely got the highest yield of interviews in the NE quadrant of the country. One my strategies was to complete away rotations in other regions that I was interested in (to both get the experience of the region and show to programs that I wasn't stuck on the NE). In my case, I chose the Midwest and Mid-eastern seaboard (some would call it the upper Southeast) for my aways. Although I did get shut out from many schools in other regions, I believe that these two rotations (believe me, I would have done more had my school not had a credit hours limit for rotations in a particular specialty area) helped open doors for me at schools in regions outside of the NE (and indeed, my top choice is outside of the NE). I would also recommend that you do your best (but don't go overboard) to explain in your personal statement why you are interested in moving to a particular region or state (family ties, etc.). I had several personal statements (ranging from those modified for specific programs to those for programs in a certain area/region). Just remember, it's a game, and you have to know/anticipate it as best you can and play it well to maneuver around the obstacles that programs may have in place (looking regionally, seeking research-experienced applicants, etc.). Remember, play your strengths, be humble, and just be yourself. If you fit, you fit... if you don't, you probably don't want to be there for 5/6 years, anyway (and programs will most likely not want you around for those 5/6 years).